"At its core FM appears to more a pain and sensory inhibiting disease than a pain producing one. Because the pain pathways in the brain need to respond like lightning to an injury, they’re essentially always on-always ready to engage. The problem in fibromyalgia is that they’re not being turned off. broken gates Several inhibitory processes seem to be broken in FM The same appears to be true with sensory inhibition and with the autonomic nervous system. The brain is not turning off its attention to innocuous stimuli and the parasympathetic nervous system is not jumping in to tone down the sympathetic or “fight and flight” system. Deficiencies in the levels of inhibitory neurotransmitters (serotonin, y-aminobutyric acid) and in the feel-good endogenous opioid system have also been seen. Fibromyalgia is looking more and more like a disorder of blunted inhibition than anything else."
Information Overload? Are Fibromyalgia Patients Brains Trying to Do Too Much?