A new study of mitochondrial DNA in ME/CFS patients has provided some important clues as to the variation of symptoms seen in patients. This study provides a rationale for outbreaks and clusters. It also accounts for both the discrepancies in Fukuda, CCC, and ICC clinical case definitions as well as the large number of possible combinations of symptoms. These case definitions may be describing the same illness, caused by the same pathogen, as it is experienced by people with distinct genetic variations.
Mitochondrial DNA and ME/CFS - One Pathogen, Many Responses