CHAOSTOCOSMOS

Monday, 3 November 2014

Small Fiber Neuropathy Fibromyalgia Studies Mount : But Does SFN Cause Pain in FM?

Researchers have quickly jumped on the small nerve fiber neuropathy (SFN) finding in Fibromyalgia. After starting out with smaller studies some bigger ones are starting to show up, and the outlines of SFN prevalence in FM are beginning to emerge.

This Greek study was not particularly big – 46 FM patients – but it was a step in the right direction. It also included a significant subset (30%) of FM patients with autoimmune disorders in its cohort. They noted that SFN is the most common type of neuropathy in Sjogren’s Syndrome, a female-dominated autoimmune disorder (that may be underdiagnosed in ME/CFS and FM). As an added bonus they also examined Langerhorn cells and stained the skin biopsies for IL-6 in a small number of patients.

In the introduction the authors went straight to the immune system – cytokines and mast cells – as a possible cause for the increased rates of SFN found in Fibromyalgia.

Small Fiber Neuropathy Fibromyalgia Studies Mount : But Does SFN Cause Pain in FM?

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