CHAOSTOCOSMOS

Sunday, 26 October 2014

New clues reveal how weight loss is regulated

The fibroblast growth factor 21 (FGF21) hormone has been a key target for developing weight-loss drugs because the protein increases energy expenditure, causing the body to burn calories. But how the hormone worked wasn't known until now.

UT Southwestern researchers tracking the hormone discovered that FGF21 acts directly on the brain, activating another hormone called corticotropin-releasing factor (CRF). CRF then stimulates the nervous system, activating brown adipose tissue, which generates body heat by burning fat.

New clues reveal how weight loss is regulated

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